ABSTRACT
The increased frequency and severe consequences of risks in the cruise industry have attracted increasing attention from both academics and practitioners, especially after the 2012 ‘Costa Concordia' disaster and the 2020 coronavirus outbreak on the ‘Diamond Princess'. Although the literature on risk studies associated with the cruise industry and supply-chain risk management is growing, the extant literature lacks a study to view risks in the cruise industry associated with the supply chain. This paper addresses this gap by reviewing the literature on risks related to the cruise industry and general supply-chain risks to create a framework of cruise supply-chain risks. Then, semi-structured interviews were conducted to validate the identified risks and explore potential undiscovered risks. A novel risk typology of the cruise supply chain was then built based on the literature review and the empirical study. This includes macro risks, safety, security, and health risks, information risks, and supply risks. This framework can be applied for the purpose of systematically identifying the risks and their impacts on the cruise supply chain. This paper contributes to the development of a comprehensive cruise supply-chain risk classification with a detailed explanation of each risk in the cruise supply chain, which can be used by stakeholders in the cruise industry to identify and measure the impact of each risk. Additionally, this paper provides avenues for future research by scholars interested in assessing and managing cruise supply-chain risks. © National Academy of Sciences: Transportation Research Board 2022.
ABSTRACT
The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 +/- 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert. Copyright © 2022 Taiwan Food and Drug Administration.
ABSTRACT
The half marathon approximately 21 kilometers started in the 1980s, and the marathon has shown a diversified development since then. The focus of this research is on the marathon in Taiwan before the COVID-19 pandemic. The selected research method is to integrate the attribute data and spatial data on the GIS platform. Preliminary information on the GIS platform shows that all types of events are held in the western part of the eastern part. The full marathon type shows that the northern metropolitan area and the central metropolitan area are the main event venues in the spatial distribution analysis. Subsequent research data shows that the spatial distribution of the city where the semi marathon is that almost all administrative regions have races. The distribution of half-marathon events is relatively balanced and almost every region has such sport events. © 2021 IEEE.
ABSTRACT
Because of the COVID-19 pandemic, telework policies have required many user experience (UX) labs to restrict their research activities to remote user testing. Automatic Facial Expression Analysis (AFEA) is an accessible psychophysiological measurement that can be easily implemented in remote user tests. However, to date, the literature on Human Computer Interaction (HCI) has provided no guidelines for remote moderated user tests that collect facial expression data and synchronize them with the state of a dynamic stimulus such as a webpage. To address this research gap, this article offers guidelines for effective AFEA data collection that are based on a methodology developed in a concrete research context and on the lessons learned from applying it in four remote moderated user testing projects. Since researchers have less control over test environment settings, we maintain that they should pay greater attention to factors that can affect face detection and\or emotion classification prior, during, and after remote moderated user tests. Our study contributes to the development of methods for including psychophysiological and neurophysiological measurements in remote user tests that offer promising opportunities for information systems (IS) research, UX design, and even digital health research. © 2021, Springer Nature Switzerland AG.
ABSTRACT
Since 2017, global oil consumption has been persistently weak, and the growth rate of consumption has been gradually declining. The impact of COVID-19 on oil demand has been "even worse". This paper reviews the trends of international crude oil prices and stock prices of large oil and gas companies since the outbreak of the epidemic, explores the impact of the epidemic on global oil demand and supply markets, studies the short-term and mid-to-long-term global oil supply and demand patterns, and draws three conclusions: firstly, the epidemic has had a major impact on global oil demand, which is expected to drop by 5% in 2020 compared with 2019. In the future, with the gradually recovery of the global economy, global oil consumption will slowly recover, and it is estimated that global oil consumption will reach a peak of 4.87 billion tons by 2030. Secondly, in the next 3~5 years, global oil production will be greater than the demand, and the global oil market will remain oversupplied for a long time to come. Thirdly, in the medium and long term, if the international crude oil price continues to fluctuate at a low price, it will cause insufficient investment in upstream exploration and development, the output of some old oil fields in the UK, Russia, Asian countries and other countries will continue to decline, and the global oil market will become tighter. © 2021, Science Press. All right reserved.
ABSTRACT
Since December 2019, an outbreak of a new coronavirus, COVID-19, infection has been taking place. At present, COVID-19 has spread to most countries worldwide. The latest evidence suggests that cytokine storm syndrome (CSS) is an important cause of the transition from mild to critical pneumonia and critically ill patients' death. The sudden exacerbation of COVID-19 may be related to a cytokine storm. Therefore, early identification and active treatment of CSS may play very important roles in improving the patients' prognosis, and these tasks are given attention in the current treatment of new Coronavirus pneumonia. However, there is still no specific medicine for this purpose. This article reviews cytokine storms and conducts an exploratory review of pharmacotherapy for cytokine storms to provide a reference for clinical treatment.